Paul M Yen Selected Research

Glycogen Storage Disease Type I

1/2019	A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia.
1/2019	Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia.
1/2017	Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa).
2/2016	Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency.

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Paul M Yen Research Topics

Disease

18	Non-alcoholic Fatty Liver Disease 12/2021 - 04/2014
5	Neoplasms (Cancer) 11/2014 - 09/2003
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 10/2016
4	Metabolic Diseases (Metabolic Disease) 01/2021 - 01/2018
4	Hyperthyroidism 04/2020 - 12/2004
4	Hypothyroidism 04/2020 - 12/2004
4	Hepatorenal form of glycogen storage disease 01/2020 - 01/2017
4	Glycogen Storage Disease Type I 01/2019 - 02/2016
3	Fibrosis (Cirrhosis) 01/2021 - 01/2016
3	Obesity 01/2021 - 06/2007
3	Fatty Liver 01/2021 - 01/2019
3	Inflammation (Inflammations) 01/2021 - 01/2017
3	Hepatocellular Carcinoma (Hepatoma) 11/2020 - 01/2014
3	Type 2 Diabetes Mellitus (MODY) 01/2018 - 12/2013
2	Hypoglycemia (Reactive Hypoglycemia) 10/2021 - 01/2020
2	Alcoholic Fatty Liver 01/2021 - 10/2017
2	Carcinoma (Carcinomatosis) 01/2020 - 02/2016
2	Insulin Resistance 01/2017 - 05/2014
2	Carcinogenesis 10/2013 - 04/2004
1	Liver Diseases (Liver Disease) 01/2021
1	Liver Cell Adenoma (Hepatocellular Adenoma) 01/2020
1	Hypertriglyceridemia 01/2020
1	Glycogen Storage Disease (Glycogenosis) 01/2020
1	Lactic Acidosis 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2019
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Frontotemporal Dementia (Semantic Dementia) 01/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019
1	Hypercholesterolemia 01/2019
1	Hyperglycemia 01/2019
1	Liver Failure 02/2016
1	Glycogen Storage Disease Type II (Pompe's Disease) 05/2014
1	Retinoblastoma (Glioblastoma, Retinal) 10/2013
1	Weight Loss (Weight Reduction) 07/2012
1	Thyrotoxicosis 12/2004

Drug/Important Bio-Agent (IBA)

12	Thyroid HormonesIBA 12/2021 - 07/2012
7	LipidsIBA 01/2021 - 01/2016
7	GlycogenIBA 01/2020 - 05/2014
4	Triglycerides (Triacylglycerol)IBA 12/2021 - 01/2018
4	Hormones (Hormone)IBA 01/2019 - 09/2003
3	FructoseIBA 12/2021 - 01/2019
3	CholesterolIBA 01/2021 - 06/2007
3	Interleukin-11 (Interleukin 11)IBA 01/2021 - 01/2019
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2016
3	Proteins (Proteins, Gene)FDA Link 11/2020 - 11/2014
3	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 01/2020 - 02/2016
3	Peptides (Polypeptides)IBA 01/2019 - 12/2008
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 01/2017
2	Methionine (L-Methionine)FDA Link 11/2021 - 01/2019
2	Iodide Peroxidase (Deiodinase)IBA 11/2021 - 11/2014
2	Choline (Choline Chloride)IBA 11/2021 - 01/2019
2	Thyroxine (Levothyroxine)FDA LinkGeneric 11/2021 - 01/2018
2	Glucagon (Glukagon)FDA Link 10/2021 - 05/2014
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2021
2	EnzymesIBA 01/2019 - 05/2014
2	CytokinesIBA 01/2019 - 12/2004
2	Glucose-6-PhosphateIBA 01/2019 - 02/2016
2	Protein Isoforms (Isoforms)IBA 10/2013 - 06/2007
1	Transcription Factors (Transcription Factor)IBA 12/2021
1	Mediator Complex Subunit 1IBA 12/2021
1	Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA 12/2021
1	Proton-Translocating ATPases (ATPase, H+)IBA 12/2021
1	Drinking WaterIBA 12/2021
1	bafilomycin A1IBA 12/2021
1	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 12/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 10/2021
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2021
1	NADPH Oxidase 4IBA 01/2021
1	Fenofibrate (CiL)FDA LinkGeneric 01/2020
1	Liver GlycogenIBA 01/2020
1	ConnectinIBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	2- ((3,5- dimethyl- 4- (4'- hydroxy- 3'- isopropylbenzyl)phenoxy)methyl)- 4- (3- chlorophenyl)- 2- oxido(1,3,2)dioxaphosphonaneIBA 01/2019
1	arginyl- 2,'6'- dimethyltyrosyl- lysyl- phenylalaninamideIBA 01/2019
1	BezafibrateIBA 01/2019
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2019
1	AntibodiesIBA 01/2019
1	acylcarnitineIBA 01/2019
1	Neutralizing AntibodiesIBA 01/2019
1	Interleukin-11 Receptors (Interleukin 11 Receptor)IBA 01/2019
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 10/2017
1	Branched-Chain Amino AcidsIBA 01/2017
1	CarbohydratesIBA 01/2017
1	CeramidesIBA 01/2017
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2017
1	PalmitatesIBA 10/2016
1	Messenger RNA (mRNA)IBA 11/2014
1	Metformin (Glucophage)FDA LinkGeneric 05/2014
1	GlucosidasesIBA 05/2014
1	AcidsIBA 05/2014
1	Caffeine (No Doz)FDA LinkGeneric 04/2014
1	ClenbuterolIBA 01/2014
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2013
1	DNA (Deoxyribonucleic Acid)IBA 10/2013
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 12/2008

Therapy/Procedure

8	Therapeutics 01/2019 - 12/2004
1	Injections 01/2019
1	Glycemic Control 05/2014